Swim training attenuates the adverse remodeling of LV structural and mechanical properties in the early compensated phase of hypertension.
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2017
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Aim: Investigate to what extent low-intensity swim training for six weeks counterbalances the adverse remodeling
due to the advance of pathological hypertrophy in the left ventricle (LV) structural and mechanical
properties in the early compensated phase of hypertension in male SHR.
Main methods: Four-month-old male SHR and Wistar rats were randomly divided into Sed (sedentary) and Ex
(exercised) groups. The exercised rats were submitted to a swimming protocol (1 h/day, 5 times/week, no additional
load) for six weeks. LV tissue and isolated myocytes were used to assess structural and mechanical
properties. Myocytes were stimulted at frequencies (F) of 1 and 3 Hz at 37 °C.
Key findings: Exercised SHR showed improvement in cardiovascular parameters compared to sedentary SHR
(mean arterial pressure: 13.22%; resting HR: 14.28.%). About structural and mechanical properties, swim
training induced a decrease in LV myocyte thickness (10.85%), number of inflammatory cells (21.24%); collagen
type III (74.23%) and type I (85.6%) fiber areas; amplitude of single myocyte shortening (47% to F1 and 28.46%
to F3), timecourses of shortening (16.5% to F1 and 7.55% to F3) and relaxation (15.31% to F3) compared to
sedentary SHR.
Significance: Six weeks of swim training attenuates the adverse remodeling of LV structural and mechanical
properties in the early compensated phase of hypertension in male SHR.
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Cardiac remodeling, Spontaneously hypertensive rats, Cardiomyocytes
Citação
LOCATELLI, J. et al. Swim training attenuates the adverse remodeling of LV structural and mechanical properties in the early compensated phase of hypertension. Life Sciences, v. 187, p. 42-49, out. 2017. Disponível em: <https://www.sciencedirect.com/science/article/pii/S0024320517303983?via%3Dihub>. Acesso em: 05 abr. 2018