Increased activity of the renin-angiotensin and sympathetic nervous systems is required for regulation of the blood pressure in rats fed a low-protein diet.
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2013
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Previous studies have shown that postweaning protein restriction induces changes in the
sympathetic nervous system in rats, leading to alterations in cardiovascular parameters. In
addition, the renin–angiotensin system is also affected in these animals. Here, we hypothesized
that adjustments in the interaction between the RAS and SNS underlie the cardiovascular
adaptations observed in rats fed a low-protein diet. Thus, we evaluated the alterations in the
mean arterial pressure (MAP) and heart rate of Fisher rats fed a protein-deficient diet before
and after systemic administration of the angiotensin-converting enzyme inhibitor enalapril and
the angiotensin II (Ang II) type 1 (AT1) receptor antagonist losartan alone or in combination
with the α1-adrenergic receptor antagonist prazosin. Administration of enalapril or losartan
decreased the MAP only of rats under protein restriction. Prazosin injection after the infusion
of losartan caused a further decrease in the MAP of malnourished rats. In contrast, only the
administrationof prazosin elicited a reductionin theMAPof control animals.Whenthe sequence
of administrationof the antagonistswasinverted, infusion of prazosin inanimals fedthe standard
or the low-protein diet induced a reduction in the MAP that was further decreased by the
subsequent injection of losartan. Importantly, in both protocols the responses ofmalnourished
animals to losartan were markedly greater when compared with the control group. Moreover,
these animals presented lower levels of circulatingAng II and a reduced responsiveness to Ang II.
In contrast, the expression of AT1 receptors in the aorta ofmalnourished animals was increased.
Thus, our data suggest that the renin–angiotensin system is an important factor supporting blood pressure in rats fed a low-protein diet and that the sympathetic nervous system activity
in these animals is under strong influence of Ang II acting via AT1 receptors.
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GOMIDE, J. M. C. et al. Increased activity of the renin-angiotensin and sympathetic nervous systems is required for regulation of the blood pressure in rats fed a low-protein diet. Experimental Physiology, v. 98, p. 57-66, 2013. Disponível em: <http://onlinelibrary.wiley.com/doi/10.1113/expphysiol.2012.066712/abstract>. Acesso em: 19 fev. 2017.