Genomic and rapid effects of aldosterone : what we know and do not know thus far.
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2016
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Aldosterone is the most known mineralocorticoid
hormone synthesized by the adrenal cortex. The genomic
pathway displayed by aldosterone is attributed to the mineralocorticoid
receptor (MR) signaling. Even though the rapid
effects displayed by aldosterone are long known, our knowledge
regarding the receptor responsible for such event is still
poor. It is intense that the debate whether the MR or another
receptor—the Bunknown receptor^—is the receptor responsible
for the rapid effects of aldosterone. Recently, G proteincoupled
estrogen receptor-1 (GPER-1) was elegantly shown
to mediate some aldosterone-induced rapid effects in several
tissues, a fact that strongly places GPER-1 as the unknown
receptor. It has also been suggested that angiotensin receptor
type 1 (AT1) also participates in the aldosterone-induced rapid
effects. Despite this open question, the relevance of the beneficial
effects of aldosterone is clear in the kidneys, colon, and
CNS as aldosterone controls the important water reabsorption
process; on the other hand, detrimental effects displayed by
aldosterone have been reported in the cardiovascular system
and in the kidneys. In this line, the MR antagonists are wellknown
drugs that display beneficial effects in patients with
heart failure and hypertension; it has been proposed that MR
antagonists could also play an important role in vascular disease,
obesity, obesity-related hypertension, and metabolic syndrome.
Taken altogether, our goal here was to (1) bring a
historical perspective of both genomic and rapid effects of
aldosterone in several tissues, and the receptors and signaling
pathways involved in such processes; and (2) critically address
the controversial points within the literature as regarding
which receptor participates in the rapid pathway display by
aldosterone.
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Mineralocorticoid receptor
Citação
HERMIDORFF, M. M. et al. Genomic and rapid effects of aldosterone: what we know and do not know thus far. Heart Failure Reviews, v. 1, p. 65-89, 2016. Disponível em: <https://link.springer.com/article/10.1007%2Fs10741-016-9591-2>. Acesso em: 15 set. 2017.