Controlled release of triamcinolone acetonide from polyurethane implantable devices: application for inhibition of inflammatory-angiogenesis.
Nenhuma Miniatura disponível
Data
2012
Título da Revista
ISSN da Revista
Título de Volume
Editor
Resumo
The purpose of this study was to develop
triamcinolone acetonide-loaded polyurethane implants (TA
PU implants) for the local treatment of different pathologies
including arthritis, ocular and neuroinflammatory
disorders. The TA PU implants were characterized by
FTIR, SAXS and WAXS. The in vitro and in vivo release
of TA from the PU implants was evaluated. The efficacy of
TA PU implants in suppressing inflammatory-angiogenesis
in a murine sponge model was demonstrated. FTIR results
revealed no chemical interactions between polymer and
drug. SAXS results indicated that the incorporation of the
drug did not disturb the polymer morphology. WAXS
showed that the crystalline nature of the TA was preserved
after incorporation into the PU. The TA released from the
PU implants efficiently inhibited the inflammatory-angiogenesis
induced by sponge discs in an experimental animal
model. Finally, TA PU implants could be used as local
drug delivery systems because of their controlled delivery
of TA.
Descrição
Palavras-chave
Citação
PINTO, F. C. H. et al. Controlled release of triamcinolone acetonide from polyurethane implantable devices: application for inhibition of inflammatory-angiogenesis. Journal of Materials Science. Materials in Medicine, v. 6, p. 1431-1445, 2012. Disponível em: <https://link.springer.com/article/10.1007%2Fs10856-012-4615-5>. Acesso em: 20 mar. 2017.