Despite Leishvaccine and Leishmune ® trigger distinct immune profiles, their ability to activate phagocytes and CD8 + T-cells support their high-quality immunogenic potential against canine visceral leishmaniasis.

Abstract

Phenotypic features of peripheral blood leukocytes have been investigated as a prerequisite to characterize the protective immunity attributed to both Leishvaccine and Leishmune ® . Our results showed that either those vaccine were accompanied by distinct profiles on innate immune compartment. While Leishvaccine promoted early changes in phenotypic fea-tures of neutrophils and eosinophils with late involvement of monocytes, Leishmune ® induced early and persistent activation of neutrophils and monocytes, without changes on eosinophil activation status. Regarding the adaptive immunity, Leishvaccine sponsored a mixed profile, associated with phenotypic changes of T and B-lymphocytes. Major phenotypic changes in CD4 + T-cells with transient activation of CD8 + T-cell, besides decreased frequency of B-cell expressing