Aerobic exercise and not a diet supplemented with jussara açaí (Euterpe edulis Martius) alters hepatic oxidative and inflammatory biomarkers in ApoE-deficient mice.
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2014
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The pulp of jussara açaí (Euterpe edulis Martius) fruit is rich in anthocyanins that exert antioxidant and anti-inflammatory effects similar to
those exerted by aerobic exercise. In the present study, we investigated the effects of jussara açaí fruit pulp consumption, either alone or in
combination with aerobic exercise, on the hepatic oxidative and inflammatory status of ApoE-deficient (ApoE 2/2) mice. Male mice were
divided into four groups (control (C), control plus açaí, exercise plus açaí (EXA) and exercise (EX)) and fed the AIN-93M diet or the
AIN-93M diet formulated to contain 2% freeze-dried açaí pulp. Mice in the EX and EXA groups were subjected to a progressive running
programme (5 d/week, 60 min/d, 16 m/min) for 12 weeks. Mice that were made to exercise exhibited reduced (40·85 %; P,0·05) hepatic
superoxide dismutase activity when compared with the C mice, independent of the açaí diet. Mice in the EX group exhibited a lower (42 %;
P,0·05) mRNA expression of monocyte chemotactic protein-1 in the liver compared with the C mice. Mice in the EXA and EX groups had
lower percentages of hepatic lipid droplets (70% and 56 %, respectively; P,0·05) when compared with the C mice. Mice in the EX group
had smaller (58 %; P,0·05) area of lesions in the aorta when compared with the C mice. Serum lipid profile was not affected (P.0·05).
In conclusion, aerobic exercise training rather than açaí fruit pulp consumption or a combination of both enhances the hepatic oxidative
and inflammatory status of ApoE 2/2 mice.
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Atherosclerosis, Anthocyanins, Antioxidants, Physical activity
Citação
CASTRO, C. A. et al. Aerobic exercise and not a diet supplemented with jussara açaí (Euterpe edulis Martius) alters hepatic oxidative and inflammatory biomarkers in ApoE-deficient mice. British Journal of Nutrition, v. 112, p. 285-294, 2014. Disponível em: <https://goo.gl/PruUsi>. Acesso em: 23 fev. 2017.