The ACE2/Angiotensin-(1-7)/MAS axis of the renin-angiotensin system : focus on Angiotensin-(1-7).
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2018
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The renin-angiotensin system (RAS) is a key player in the control of the cardiovascular system and
hydroelectrolyte balance, with an influence on organs and functions throughout the body. The
classical view of this system saw it as a sequence of many enzymatic steps that culminate in
the production of a single biologically active metabolite, the octapeptide angiotensin (ANG) II, by the
angiotensin converting enzyme (ACE). The past two decades have revealed new functions for some
of the intermediate products, beyond their roles as substrates along the classical route. They may
be processed in alternative ways by enzymes such as the ACE homolog ACE2. One effect is to
establish a second axis through ACE2/ANG-(1–7)/MAS, whose end point is the metabolite ANG-
(1–7). ACE2 and other enzymes can form ANG-(1–7) directly or indirectly from either the decapeptide
ANG I or from ANG II. In many cases, this second axis appears to counteract or modulate
the effects of the classical axis. ANG-(1–7) itself acts on the receptor MAS to influence a range of
mechanisms in the heart, kidney, brain, and other tissues. This review highlights the current
knowledge about the roles of ANG-(1–7) in physiology and disease, with particular emphasis on the
brain.
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SANTOS, R. A. S. dos et al. The ACE2/Angiotensin-(1-7)/MAS axis of the renin-angiotensin system : focus on Angiotensin-(1-7). Physiological Reviews, v. 98, n. 1, p. 505-553, jan. 2018. Disponível em: <https://www.physiology.org/doi/abs/10.1152/physrev.00023.2016>. Acesso em: 14 nov. 2018.