Effects of the aqueous extract from Tabebuia roseoalba and phenolic acids on hyperuricemia and inflammation.

dc.contributor.authorFerraz Filha, Zilma Schimith
dc.contributor.authorFerrari, Fernanda Cristina
dc.contributor.authorAraújo, Marcela Carolina de Paula Michel
dc.contributor.authorBernardes, Ana Catharina Fernandes Pereira Ferreira
dc.contributor.authorGuimarães, Dênia Antunes Saúde
dc.date.accessioned2019-04-15T14:36:46Z
dc.date.available2019-04-15T14:36:46Z
dc.date.issued2017
dc.description.abstractTabebuia species (Bignoniaceae) have long been used in folk medicine as anti-inflammatory, antirheumatic, antimicrobial, and antitumor. The aim of this study was to investigate if aqueous extract from the leaves (AEL) of Tabebuia roseoalba (Ridl.) Sandwith, Bignoniaceae, and its constituents could be useful to decrease serum uric acid levels and restrain the gout inflammatory process. HPLC analysis identified caffeic acid and chlorogenic acid in AEL. Antihyperuricemic effects and inhibition of liver XOD (xanthine oxidoreductase) by AEL and identified compounds were evaluated in hyperuricemic mice. Anti-inflammatory activity was evaluated on MSU (monosodium urate) crystal-induced paw edema. In addition, AEL antioxidant activity in vitro was evaluated. AEL, caffeic, and chlorogenic acids were able to reduce serum uric acid levels in hyperuricemic mice probably through inhibition of liver xanthine oxidase activity and significantly decreased the paw edema induced by MSU crystals. AEL showed significant antioxidant activity in all evaluated assays. The results show that the AEL of Tabebuia roseoalba can be a promising agent for treatment for gout and inflammatory diseases. We suggest that caffeic and chlorogenic acids may be responsible for the activities demonstrated by the species.pt_BR
dc.identifier.citationFERRAZ FILHA, Z. S. et al. Effects of the aqueous extract from Tabebuia roseoalba and phenolic acids on hyperuricemia and inflammation. Evidence-based Complementary and Alternative Medicine, v. 2017, p. 1-11, 2017. Disponível em: <https://www.hindawi.com/journals/ecam/2017/2712108/>. Acesso em: 25 fev. 2019.pt_BR
dc.identifier.issn17414288
dc.identifier.urihttp://www.repositorio.ufop.br/handle/123456789/11017
dc.language.isoen_USpt_BR
dc.rightsabertopt_BR
dc.rights.licenseThis is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Fonte: o próprio artigopt_BR
dc.titleEffects of the aqueous extract from Tabebuia roseoalba and phenolic acids on hyperuricemia and inflammation.pt_BR
dc.typeArtigo publicado em periodicopt_BR

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