Bezold-Jarisch reflex in sino-aortic denervated malnourished rats.

dc.contributor.authorBezerra, Vanessa Moraes
dc.contributor.authorXavier, Carlos Henrique
dc.contributor.authorMenezes, Rodrigo Cunha Alvim de
dc.contributor.authorFontes, Marco Antônio Peliky
dc.contributor.authorCardoso, Leonardo Máximo
dc.contributor.authorFernandes, Luciano Gonçalves
dc.contributor.authorChianca Júnior, Deoclécio Alves
dc.date.accessioned2012-11-26T11:16:37Z
dc.date.available2012-11-26T11:16:37Z
dc.date.issued2011
dc.description.abstractIn this study we assessed the role of Bezold–Jarisch reflex (BJR) in the regulation of blood pressure (BP) of malnourished (MN) and control rats (CN) with sino-aortic denervation (SAD). Fischer rats were fed diets containing either 6% (MN) or 15% (CN) protein for 35 days after weaning. These rats underwent sham or SAD and catheterization of femoral artery and vein for BP measurements and drug injection. Phenylbiguanide (PBG 5 μg/kg, i.v.) for activation BJR, produced bradycardia (− 317 ± 22 bpm for CN vs. − 372 ± 16 bpm for MN) and hypotension (− 57 ± 4 mm Hg for CN vs. − 54 ± 6 mm Hg for MN. After SAD, MN rats had reduced hypotensive (− 37 ± 7 mmHg for MN vs. − 82 ± 6 mm Hg for CN) and bradycardic (− 124 ± 17 for MN vs. − 414 ± 20 bpm CN) responses to BJR activation. To evaluate the contribution of the parasympathetic component due to BJR for the fall in BP, methyl atropine bromide, was given between two injections of PBG (5 μg/kg) separated by 10 min each other. Both bradycardic (− 216 ± 21 bpm before and − 4±3 bpm after for CN − 226±43 bpm before and − 9±20 bpm after for MN) and hypotensive (− 42±4 mm Hg before and − 6±1 mm Hg after for CN − 33±9 mm Hg before and − 5±2 mm Hg after for MN) responses were abolished in CN and MN groups. These data indicate that dietary protein malnutrition changes the relation between baroreflex and BJR required for maintenance of the BP during malnourishment.pt_BR
dc.identifier.citationBEZERRA, V. M. et al. Bezold-Jarisch reflex in sino-aortic denervated malnourished rats. Autonomic Neuroscience: Basic and Clinical, v. 162, n. 1-2, p. 48-53, jul. 2011. Disponível em: <https://www.sciencedirect.com/science/article/pii/S1566070211000671>. Acesso em: 26 nov. 2012.pt_BR
dc.identifier.issn15660702
dc.identifier.urihttp://www.repositorio.ufop.br/handle/123456789/1804
dc.language.isoen_USpt_BR
dc.rights.licenseO periódico Autonomic Neuroscience: Basic & Clinical concede permissão para depósito deste artigo no Repositório Institucional da UFOP. Número da licença: 3314370203207.
dc.subjectBezold-Jarisch reflexpt_BR
dc.subjectSino-aortic denervationpt_BR
dc.subjectProtein malnourishmentpt_BR
dc.titleBezold-Jarisch reflex in sino-aortic denervated malnourished rats.pt_BR
dc.typeArtigo publicado em periodicopt_BR

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