Computational identification and evolutionary relationships of the MicroRNA gene cluster miR-71/2 in protostomes.

Nenhuma Miniatura disponível
Data
2013
Título da Revista
ISSN da Revista
Título de Volume
Editor
Resumo
MicroRNAs (miRNAs) are small noncoding RNA molecules which are processed into *20–24 nt molecules that can regulate the gene expression posttranscriptionally. MiRNA gene clusters have been identified in a range of species, where in miRNAs are often processed from polycistronic transcripts. In this study, a computational approach is used to investigate the extent of evolutionary conservation of the miR-71/2 cluster in animals, and to identify novel miRNAs in the miRNA cluster miR-71/2. The miR-71/2 cluster, consisting of copies of the miR-71 and miR-2 (including miR-13) families, was found to be Protostome-specific. Although, this cluster is highly conserved across the Protostomia, the miR-2 family is completely absent from the Deuterostomia species, while miR-71 is absent from the Vertebrata and Urochordata. The evolutionary conservation and clustering propensity of the miR-71/2 family across the Protostomes could indicate the common functional roles across the member species of the Protostomia.
Descrição
Palavras-chave
Citação
GOMES, M. de S. et al. Computational identification and evolutionary relationships of the MicroRNA gene cluster miR-71/2 in protostomes. Journal of Molecular Evolution, v. 76, p. 353-358, 2013. Disponível em: <https://link.springer.com/article/10.1007%2Fs00239-013-9563-2>. Acesso em: 23 fev. 2017.