The role of IL‐10 in immune responses against Pseudomonas aeruginosa during acute lung infection.
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2020
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Resumo
Pseudomonas aeruginosa is considered an opportunistic pathogen of great clinical importance. The clearance of this bac-
terium occurs through recognition of the pathogen by innate immune system receptors, leading to a lung infammatory
response. However, this response must be controlled via immunoregulatory pathways. In this study, we evaluate the role
of endogenous murine IL-10 after acute infection with the virulent strain P. aeruginosa PA14. To assess the role of IL-10,
intratracheal infection with the PA14 strain was performed in C57BL/6 or IL-10 KO mice. The PA14 strain was recovered
in both types of animals, although IL-10 KO mice presented a higher number of viable bacteria in the lung when compared
to the C57BL/6 group. Histopathological and stereological analyses showed that IL-10 KO mice had higher tissue damage
and infammatory infltrate when compared to control animals. The activity of MMP-9 but not MMP-2, as well as IL-6 and
TNF-α expression, were augmented in the lungs of infected animals and was much more evident in IL-10 KO animals when
compared to the other analyzed groups. This work indicates that endogenous IL-10 control P. aeruginosa infection, the
expression of pro-infammatory genes, MMP-9 activity and histopathological processes of the infectious process in question.
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Immunoregulation, Interleukin-10, Lung infection, Infammatory response
Citação
BELO, V. A. et al. The role of IL‐10 in immune responses against Pseudomonas aeruginosa during acute lung infection. Cell and tissue research, v. 383, p. 1123–1133, 2020. Disponível em: <https://link.springer.com/article/10.1007/s00441-020-03308-4#:~:text=Despite%20the%20onset%20of%20the,Apidianakis%202013%3B%20Hazlett%20et%20al.>. Acesso em: 11 out. 2022.