Formulations with microencapsulated Fe–peptides improve in vitro bioaccessibility and bioavailability.

Resumo
The bioaccessibility and the bioavailability of iron complexed to peptides (active) in microparticles forms con- tained in dry beverages formulations were evaluated. The peptide-iron complexes microparticles were obtained by spray drying and added in three dry formulations (tangerine, strawberry, and chocolate flavors). The peptides isolated by iron ion affinity (IMAC-Fe III) had their biological activity predicted by BIOPEP® database and were evaluated by molecular coupling. The bioaccessibility was evaluated by solubility and dialysability and the bioavalability was assessed by Caco-2 cellular model. The proportion 10:1 of peptide-iron complexes presented higher rates of bioaccessibility (49%) and bioavailability (56%). The microparticle with peptide-iron complex showed greater solubility after digestion (39.1%), bioaccessibility (19.8%), and bioavailability (34.8%) than the ferrous sulfate salt (control) for the three assays (10.2%; 12.9%; 9.7%, respectively). Tangerine and strawberry formulations contributed to the iron absorption according to the results of bioaccessibility (36.2%, 30.0% respectively) and bioavailability (80.5%, 84.1%, respectively). The results showed that iron peptide complexa- tion and microencapsulation process improve the bioaccessibility and bioavailability when incorporated into formulations.
Descrição
Palavras-chave
Dialyzability, Molecular coupling
Citação
GAIGHER, B. et al. Formulations with microencapsulated Fe–peptides improve in vitro bioaccessibility and bioavailability. Current Research in Food Science, v. 5, p. 687–697, 2022. Disponível em: <https://www.sciencedirect.com/science/article/pii/S2665927122000491>. Acesso em: 11 out. 2022.