Effect of pyridostigmine on in vivo and in vitro respiratory muscle of mdx mice.

dc.contributor.authorAmancio, Gabriela de Cássia Sousa
dc.contributor.authorGuimarães, Andrea Grabe
dc.contributor.authorHaikel, Dridi
dc.contributor.authorMoreau, Johan
dc.contributor.authorBarcellos, Neila Marcia Silva
dc.contributor.authorLacampagne, Alain
dc.contributor.authorMatecki, Stefan
dc.contributor.authorCazorla, Olivier
dc.date.accessioned2019-04-15T14:12:13Z
dc.date.available2019-04-15T14:12:13Z
dc.date.issued2017
dc.description.abstractThe current work was conducted to verify the contribution of neuromuscular transmission defects at the neuromuscular junction to Duchenne Muscular Dystrophy disease progression and respiratory dysfunction. We tested pyridostigmine and pyridostigmine encapsulated in liposomes (liposomal PYR), an acetylcholinesterase inhibitor to improve muscular contraction on respiratory muscle function in mdx mice at different ages. We evaluated in vivo with the whole-body plethysmography, the ventilatory response to hypercapnia, and measured in vitro diaphragm strength in each group. Compared to C57BL10 mice, only 17 and 22 month-old mdx presented blunted ventilatory response, under normocapnia and hypercapnia. Free pyridostigmine (1 mg/kg) was toxic to mdx mice, unlike liposomal PYR, which did not show any side effect, confirming that the encapsulation in liposomes is effective in reducing the toxic effects of this drug. Treatment with liposomal PYR, either acute or chronic, did not show any beneficial effect on respiratory function of this DMD experimental model. The encapsulation in liposomes is effective to abolish toxic effects of drugs.pt_BR
dc.identifier.citationAMANCIO, D. de C. S. et al. Effect of pyridostigmine on in vivo and in vitro respiratory muscle of mdx mice. Respiratory Physiology & Neurobiology, v. 243, p. 107-114, set. 2017. Disponível em: <https://www.sciencedirect.com/science/article/pii/S1569904817300691?via%3Dihub>. Acesso em: 25 fev. 2019.pt_BR
dc.identifier.issn15699048
dc.identifier.urihttp://www.repositorio.ufop.br/handle/123456789/11012
dc.identifier.uri2https://www.sciencedirect.com/science/article/pii/S1569904817300691pt_BR
dc.language.isoen_USpt_BR
dc.rightsrestritopt_BR
dc.subjectDuchenne muscular dystrophypt_BR
dc.subjectPyridostigmine bromidept_BR
dc.subjectRespiratory functionpt_BR
dc.subjectDiaphragm contractilitypt_BR
dc.subjectPletysmographypt_BR
dc.titleEffect of pyridostigmine on in vivo and in vitro respiratory muscle of mdx mice.pt_BR
dc.typeArtigo publicado em periodicopt_BR

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