Oral pregabalin is effective as preemptive analgesia in abdominal hysterectomy - a randomized controlled trial.

dc.contributor.authorSilva, Fabrício Gomes da
dc.contributor.authorPodestá, Márcia Helena Miranda Cardoso
dc.contributor.authorSilva, Thayná Coelho
dc.contributor.authorBarros, Carlos Marcelo de
dc.contributor.authorCarvalho, Breno Fialho Vitarelli de
dc.contributor.authorReis, Tiago Marques dos
dc.contributor.authorEsposito, Milena Carla
dc.contributor.authorMarrafon, Danielle Aparecida Ferreira de Oliveira
dc.contributor.authorNogueira, Denismar Alves
dc.contributor.authorDiwan, Sudhir
dc.contributor.authorCeron, Carla Speroni
dc.contributor.authorTorres, Larissa Helena
dc.date.accessioned2023-12-13T21:13:17Z
dc.date.available2023-12-13T21:13:17Z
dc.date.issued2022pt_BR
dc.description.abstractPostoperative pain is one of the main negative symptoms resulting from surgery and the use of new methods to control this symptom is of ever-increasing relevance. Opioid-sparing strategies, such as multimodal analgesia, are trends in this scenario. Pregabalin is a well-established treatment for neuropathic pain; however, it is still controversial in the surgical context for postoperative analgesia. This study investigated the effect of pregabalin on postoperative analgesia in patients undergoing abdominal hysterectomy. It is a prospective, randomised, double-blind, placebo-controlled clinical trial. Female patients undergoing abdominal hysterectomy were randomised to use pregabalin (group P1), 300 mg orally 2 h before surgery, or identical placebo pills (group P0). The main outcome includes the postoperative pain index by visual analogue scale (VAS) and McGill's pain questionnaire. Secondary outcomes include opioid consumption and the presence of adverse effects. A value of p < 0.05 was used to reject type I error. Fifty-five patients were randomised amongst the groups. Patients in group P1 had lower pain rates by VAS scale, both at rest and in active motion, than group P0. In McGill's questionnaire, patients from group P1 also had lower pain rates (12 28.5). There was approximately twice as much opioid consumption amongst patients in group P0. Regarding side effects, there was a difference between the two groups only for dizziness, being more incident in group P1. This study suggests that pregabalin is an important adjuvant drug in treating postoperative pain in patients with abdominal hysterectomy.pt_BR
dc.identifier.citationSILVA, F. G. da et al. Oral pregabalin is effective as preemptive analgesia in abdominal hysterectomy - a randomized controlled trial. Clinical and Experimental Pharmacology & Physiology, v. 50, n. 3, p. 256-263, mar. 2022. Disponível em: <https://onlinelibrary.wiley.com/doi/full/10.1111/1440-1681.13742>. Acesso em: 01 ago. 2023.pt_BR
dc.identifier.doihttps://doi.org/10.1111/1440-1681.13742pt_BR
dc.identifier.issn0305-1870
dc.identifier.urihttp://www.repositorio.ufop.br/jspui/handle/123456789/17932
dc.identifier.uri2https://onlinelibrary.wiley.com/doi/full/10.1111/1440-1681.13742pt_BR
dc.language.isoen_USpt_BR
dc.rightsrestritopt_BR
dc.subjectMultimodal analgesiapt_BR
dc.subjectPostoperative analgesiapt_BR
dc.subjectPostoperative painpt_BR
dc.subjectPreemptive analgesiapt_BR
dc.subjectPregabalinpt_BR
dc.titleOral pregabalin is effective as preemptive analgesia in abdominal hysterectomy - a randomized controlled trial.pt_BR
dc.typeArtigo publicado em periodicopt_BR

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