Magnesium (Mg2+), Strontium (Sr2+), and Zinc (Zn2+) Co‑substituted bone cements based on nano‑hydroxyapatite/ monetite for bone regeneration.
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2022
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New bone cement type that combines Sr2+/Mg2+or Sr2+/Zn2+co-substituted nano-hydroxyapatite (n-HAs) with calcium
phosphate dibasic and chitosan/gelatin polymers was developed to increase adhesion and cellular response. The cements
were physicochemically described and tested in vitro using cell cultures. All cements exhibited quite hydrophilic and had
high washout resistance. Cement releases Ca2+, Mg2+, Sr2+, and Zn2+in concentrations that are suitable for osteoblast
proliferation and development. All of the cements stimulated cell proliferation in fbroblasts, endothelial cells, and osteoblasts,
were non-cytotoxic, and produced apatite. Cements containing co-substituted n-HAs had excellent cytocompatibility, which
improved osteoblast adhesion and cell proliferation. These cements had osteoinductive potential, stimulating extracellular
matrix (ECM) mineralization and diferentiation of MC3T3-E1 cells by increasing ALP and NO production. The ions Ca2+,
Mg2+, Zn2+, and Sr2+appear to cooperate in promoting osteoblast function. The C3 cement (HA-SrMg5%), which was
made up of n-HA co-substituted with 5 mol% Sr and 5 mol% Mg, showed exceptional osteoinductive capacity in terms of
bone regeneration, indicating that this new bone cement could be a promising material for bone replacement.
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Co-substituted hydroxyapatite, Monetite, Chitosan, Gelatin, Bone cement
Citação
DIAS, A. M. et al. Magnesium (Mg2+), Strontium (Sr2+), and Zinc (Zn2+) Co‑substituted bone cements based on nano‑hydroxyapatite/ monetite for bone regeneration. Biological Trace Element Research, v. 201, p. 2963–2981, 2022. Disponível em: <https://link.springer.com/article/10.1007/s12011-022-03382-5>. Acesso em: 01 ago. 2023.