Synthesis of novel papulacandin D analogs and evaluation of their antifungal potential.
dc.contributor.author | Bretas, Ana Carolina Oliveira | |
dc.contributor.author | Souza, Thiago Belarmino de | |
dc.contributor.author | Borelli, Beatriz | |
dc.contributor.author | Johan, Suzana | |
dc.contributor.author | Alves, Ricardo José | |
dc.date.accessioned | 2021-12-07T21:03:28Z | |
dc.date.available | 2021-12-07T21:03:28Z | |
dc.date.issued | 2020 | pt_BR |
dc.description.abstract | Systemic fungal infections are a growing problem in contemporary medicine and few drugs are licensed for therapy of invasive fungal infections. Differences between fungi and humans, like the presence of a cell wall in fungal cells, can be explored for designing new drugs. (1,3)-β-D-glucan synthase, an enzyme that catalyzes the synthesis of (1,3)-β-D-glucan, a structural and essential component of the fungal cell wall, is absent in mammals and this makes it an excellent target for the development of new antifungal agents. Papulacandins are a family of natural antifungal agents targeting (1,3)-β-D-glucan synthase. In this study we describe the synthesis and biological evaluation of two new Papulacandin analogs as potential (1,3)-β-D-glucan synthase inhibitors. | pt_BR |
dc.identifier.citation | BRETAS, A. C. O. et al. Synthesis of novel papulacandin D analogs and evaluation of their antifungal potential. Brazilian Journal of Pharmaceutical Sciences, v. 56, 2020. Disponível em: <https://www.scielo.br/j/bjps/a/9WyRKPhrqfMknLVVr9ZFnhj/>. Acesso em: 10 jun. 2021. | pt_BR |
dc.identifier.doi | https://doi.org/10.1590/s2175-97902019000417652 | pt_BR |
dc.identifier.issn | 2175-9790 | |
dc.identifier.uri | http://www.repositorio.ufop.br/jspui/handle/123456789/14116 | |
dc.language.iso | en_US | pt_BR |
dc.rights | aberto | pt_BR |
dc.rights.license | This is an open-access article distributed under the terms of the Creative Commons Attribution License. Fonte: o PDF do artigo. | pt_BR |
dc.subject | β-(1,3)-D-glucan synthase | pt_BR |
dc.subject | Molecular simplification | pt_BR |
dc.title | Synthesis of novel papulacandin D analogs and evaluation of their antifungal potential. | pt_BR |
dc.type | Artigo publicado em periodico | pt_BR |