Synthesis of novel papulacandin D analogs and evaluation of their antifungal potential.

dc.contributor.authorBretas, Ana Carolina Oliveira
dc.contributor.authorSouza, Thiago Belarmino de
dc.contributor.authorBorelli, Beatriz
dc.contributor.authorJohan, Suzana
dc.contributor.authorAlves, Ricardo José
dc.date.accessioned2021-12-07T21:03:28Z
dc.date.available2021-12-07T21:03:28Z
dc.date.issued2020pt_BR
dc.description.abstractSystemic fungal infections are a growing problem in contemporary medicine and few drugs are licensed for therapy of invasive fungal infections. Differences between fungi and humans, like the presence of a cell wall in fungal cells, can be explored for designing new drugs. (1,3)-β-D-glucan synthase, an enzyme that catalyzes the synthesis of (1,3)-β-D-glucan, a structural and essential component of the fungal cell wall, is absent in mammals and this makes it an excellent target for the development of new antifungal agents. Papulacandins are a family of natural antifungal agents targeting (1,3)-β-D-glucan synthase. In this study we describe the synthesis and biological evaluation of two new Papulacandin analogs as potential (1,3)-β-D-glucan synthase inhibitors.pt_BR
dc.identifier.citationBRETAS, A. C. O. et al. Synthesis of novel papulacandin D analogs and evaluation of their antifungal potential. Brazilian Journal of Pharmaceutical Sciences, v. 56, 2020. Disponível em: <https://www.scielo.br/j/bjps/a/9WyRKPhrqfMknLVVr9ZFnhj/>. Acesso em: 10 jun. 2021.pt_BR
dc.identifier.doihttps://doi.org/10.1590/s2175-97902019000417652pt_BR
dc.identifier.issn2175-9790
dc.identifier.urihttp://www.repositorio.ufop.br/jspui/handle/123456789/14116
dc.language.isoen_USpt_BR
dc.rightsabertopt_BR
dc.rights.licenseThis is an open-access article distributed under the terms of the Creative Commons Attribution License. Fonte: o PDF do artigo.pt_BR
dc.subjectβ-(1,3)-D-glucan synthasept_BR
dc.subjectMolecular simplificationpt_BR
dc.titleSynthesis of novel papulacandin D analogs and evaluation of their antifungal potential.pt_BR
dc.typeArtigo publicado em periodicopt_BR

Arquivos

Pacote original

Agora exibindo 1 - 1 de 1
Imagem de Miniatura
Nome:
ARTIGO_SynthesisNovelPapulacandi.pdf
Tamanho:
784.08 KB
Formato:
Adobe Portable Document Format
Descrição:

Licença do pacote

Agora exibindo 1 - 1 de 1
Nenhuma Miniatura Disponível
Nome:
license.txt
Tamanho:
1.71 KB
Formato:
Item-specific license agreed upon to submission
Descrição: