The intake of flavonoids, stilbenes, and tyrosols, mainly consumed through red wine and virgin olive oil, is associated with lower carotid and femoral subclinical atherosclerosis and coronary calcium.
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2022
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Purpose It is suggested that polyphenols back the cardiovascular protection ofered by the Mediterranean diet. This study
evaluates the association of specifc types of dietary polyphenols with prevalent subclinical atherosclerosis in middle-aged
subjects.
Methods Ultrasonography and TC were performed on 2318 men from the Aragon Workers Health Study, recruited between
2011 and 2014, to assess the presence of plaques in carotid and femoral arteries and coronary calcium. Polyphenol intake
was assessed using a validated semi-quantitative 136-item food frequency questionnaire. The Phenol Explorer database was
used to derive polyphenol class intake. Logistic and linear regressions were used to estimate the cross-sectional association
of polyphenols intake with femoral and carotid subclinical atherosclerosis and coronary calcium.
Results A higher intake of favonoids (third vs. frst tertile) was associated with a lower risk of both carotid (OR 0.80: CI
95% 0.62–1.02; P trend 0.094) and femoral (0.62: 0.48–0.80, P trend<0.001) subclinical atherosclerosis. A higher intake
of stilbenes was associated with a lower risk of femoral subclinical atherosclerosis (0.62: 0.46–0.83; P trend 0.009) and
positive coronary calcium (0.75: 0.55–1.03; P trend 0.131). A higher intake of tyrosols was also associated with a lower risk
of positive coronary calcium (0.80: 0.62–1.03; P trend 0.111). The associations remained similar when adjusted for blood
lipids and blood pressure.
Conclusion Dietary favonoids, stilbenes, and tyrosols, whose main sources are red wine and virgin olive oil, are associated
with lower prevalence of subclinical atherosclerosis in middle-aged subjects.
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Cross-sectional cohort study, Subclinical coronary atherosclerosis
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SALAZAR, H. M. et al. The intake of flavonoids, stilbenes, and tyrosols, mainly consumed through red wine and virgin olive oil, is associated with lower carotid and femoral subclinical atherosclerosis and coronary calcium. European journal of nutrition, v. 61, p. 2697–2709, 2022. Disponível em: <https://link.springer.com/article/10.1007/s00394-022-02823-0>. Acesso em: 11 out. 2022.